Acomplia is a highly-efficient weight loss agent that can help you lose up to 10% of your body mass in the first year of the treatment, provided that you take this medicine exactly as prescribed. Acomplia is very well tolerated and such mild side effects as nausea and vomiting are reported most commonly. However, in some cases patients taking rimonabant have reported a number of psychiatric symptoms, such as insomnia, anxiety, aggression, agitation, panic attacks, and, in some cases, even depressive symptoms and suicidal tendencies. If you develop any of those - make sure you contact your health care provider as soon as possible to see if you need a dose adjustment or taking rimonabant is not safe for you. Your health care provider must be notified if you are also using HIV medications, rifampicin, depression medications, antidepressants, antibiotics, epilepsy drugs, medicines for weight loss, antifungals, drugs for normal blood lipid levels, St. John's wort, and antidiabetes medications. Some of these drugs can cause dangerous interactions with rimonabant and are not supposed to be combined with it. If you have impaired kidney function, liver problems, or a history of epilepsy, make sure your doctor is aware of that before prescribing this medication.